Condition Overview

Huntington’s disease is a genetic disorder that causes nerve cells in the brain to break down, affecting both the mind and the body of the patient.  

The first signs of the disease are usually subtle changes in mood or mental abilities. In time, a lack of coordination and unsteadiness become apparent. As the disease progresses, it becomes more and more difficult to control the body. Jerky body movements are common, and eventually, the patient is unable to walk. The disease also affects the mind, eventually leading to dementia.

Other symptoms include muscle spasm, compulsive behavior, fidgeting, irritability, lack of restraint, paranoia, anxiety and depression.  

There is no cure for Huntington’s disease, although treatment can slow the progression.


Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease

The endocannabinoid pathway in Huntington's disease: A comparison with other neurodegenerative diseases

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease

The role of Cannabinoids in neurodegenerative diseases

Interesting Fact

A 2015 study in the journal Neurotherapeutics found that Cannabigerol (CBG), one of the lesser known cannabinoids in marijuana, reduced the accumulation of mutant Huntington protein which may be responsible for many of the symptoms of the disease.